Document Details

Document Type : Article In Journal 
Document Title :
dRHP-PseRA: detecting remote homology proteins using profile-based pseudo protein sequence and rank aggregation
dRHP-PseRA: detecting remote homology proteins using profile-based pseudo protein sequence and rank aggregation
 
Document Language : English 
Abstract : Protein remote homology detection is an important task in computational proteomics. Some computational methods have been proposed, which detect remote homology proteins based on different features and algorithms. As noted in previous studies, their predictive results are complementary to each other. Therefore, it is intriguing to explore whether these methods can be combined into one package so as to further enhance the performance power and application convenience. In view of this, we introduced a protein representation called profile-based pseudo protein sequence to extract the evolutionary information from the relevant profiles. Based on the concept of pseudo proteins, a new predictor, called “dRHP-PseRA”, was developed by combining four stateof- the-art predictors (PSI-BLAST, HHblits, Hmmer, and Coma) via the rank aggregation approach. Cross-validation tests on a SCOP benchmark dataset have demonstrated that the new predictor has remarkably outperformed any of the existing methods for the same purpose on ROC50 scores. Accordingly, it is anticipated that dRHP-PseRA holds very high potential to become a useful high throughput tool for detecting remote homology proteins. For the convenience of most experimental scientists, a web-server for dRHP-PseRA has been established at http://bioinformatics.hitsz.edu.cn/ dRHP-PseRA/. 
ISSN : 2045-2322 
Journal Name : Scientific reports 
Volume : 6 
Issue Number : 1 
Publishing Year : 1437 AH
2016 AD 
Article Type : Article 
Added Date : Monday, July 17, 2017 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
Junjie ChenChen, Junjie ResearcherDoctorate 
Ren LongLong, Ren ResearcherDoctorate 
Xiao-long WangWang, Xiao-long ResearcherDoctorate 
Bin LiuLiu, Bin ResearcherDoctorate 
Kuo-Chen ChouChou, Kuo-Chen ResearcherDoctorate 

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